Master Project in Nanoscience: Formation Kinetics of Liquid-LiquidePhase Separation by Microfluidics

Liquid-Liquid phase separation (LLPS) is a recently emerging and fascinating concept of cellular organization. LLPS describes the physical principle of spontaneous de-mixing of a multi-component system (solution) into multiple spatially separated liquid phases of high respectively low density. Cellular structures formed by LLPS are commonly referred as membrane-less organelles (MLOs) and are thought to play a key role in the spatial-temporal orchestration of complex biochemical reactions in cells. Our Lab tries to understand how a particular group of proteins, the Dead-Box ATPases (DDXs), regulates LLPS and the formation of MLOs from a bio-physical/chemical and cellular point of view.